Core Objectives: Enhancing Clinical Safety and Efficacy
● Improving Coating Load-Bearing and Drug Release Capacity (for Drug-Eluting Balloons): For drug-eluting balloons, the hydrophilic coating serves as the underlying layer for drug delivery. Its uniform membrane structure allows for precise loading of antiproliferative drugs such as paclitaxel and rapamycin, while controlling the drug release rate to achieve "local high concentration, long-lasting sustained release," reducing systemic drug side effects and lowering the rate of restenosis.
● Preventing Balloon Adhesion to Tissue: After balloon inflation, smooth retraction is crucial. Uncoated balloons may adhere tightly to the vessel wall during inflation, leading to adhesion and potentially tearing the vascular intima during retraction, causing complications such as thrombosis and bleeding. The lubricity of the hydrophilic coating effectively prevents adhesion, ensuring smooth balloon retraction and reducing the risk of postoperative adverse reactions.
Advantages of Shanghai Yangmi Ultrasonic Spraying Technology
● High Coating Uniformity: Ultrasonic spraying generates micron-sized droplets, forming a hydrophilic coating with a thickness deviation of <5% on the balloon surface. This avoids the localized accumulation or missed coating problems of traditional spraying, ensuring smooth balloon catheter delivery and biocompatibility.
● High Material Utilization: Compared to dip coating and brush coating, ultrasonic spraying reduces material loss by more than 60%, significantly saving expensive medical hydrophilic coating materials (such as PVP and polyacrylic acid).
● Non-Damaging Spraying: The low-temperature atomization process avoids high-pressure airflow impact, preventing stretching or damage to the thin balloon wall, making it suitable for various medical balloons (such as coronary dilation balloons and valvuloplasty balloons).
● High Precision and Controllability: The coating thickness (adjustable from 0.5-10μm) can be precisely controlled by adjusting the ultrasonic frequency (50-120kHz), nozzle movement speed, and spraying distance to meet the coating performance requirements of different clinical scenarios.
