Ultrasound-sprayed paclitaxel balloon catheter

Preparation of drug balloon catheter by ultrasonic spraying -- Drug coating -- YMUS ultrasonic spraying

Ultrasonic spraying is a technology that uses ultrasonic waves to convert liquid into micron particle size droplets. In the ultrasonic spraying process, the liquid is sprayed out through the spray nozzle through the ultrasonic vibrator, forming tiny droplets, and then these droplets fall evenly onto the surface of the product. In this spraying technology, the vibration effect of ultrasonic waves helps to produce uniform and fine droplets, providing better coverage and droplet dispersion.

Paclitaxel is a commonly used anti-cancer drug that is widely used to treat a variety of cancers, such as breast, ovarian, lung, etc. The purpose of applying ultrasonic spray of paclitaxel on balloon catheter is to evenly coat the surface of balloon catheter to achieve better drug release effect.

Paclitaxel is dissolved in a suitable solvent, usually ethanol and dimethyl sulfoxide (DMSO). Set the position of the ultrasonic spraying tool. Fix the balloon catheter under the spray nozzle in the ultrasonic spraying device to ensure uniform spraying. Parameters such as ultrasonic frequency, power, and spray speed are adjusted to produce droplets of the right size and density. The adjustment of these parameters can be determined based on the desired coating thickness and drug release rate. Ultrasonic vibrations disperse the solution into tiny droplets, which are then ejected onto the surface of the balloon catheter. After spraying, the droplets form a film on the balloon catheter. Proper drying and curing steps are usually required to ensure adherence and stability of the drug on the balloon catheter.

YMUS ultrasonic spray of paclitaxel on balloon catheter can achieve uniform drug distribution and better adhesion, and improve the drug release effect of balloon catheter. This method has important clinical application potential in interventional radiology, cardiovascular and cerebrovascular fields.